Congrats to co-first authors Joon, Alberto, and Mindy on the publication of their manuscript: Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers.
What a great paper!!
Congratulations Alberto! /
Alberto recently won the poster prize at the TPCB retreat, and just had a new paper posted on ChemRxiv!
https://chemrxiv.org/engage/chemrxiv/article-details/6501276cb6ab98a41c59bd99
Welcome New Lab Members! /
The lab welcomes postdoctoral fellows Luca Posa, PhD./PharmD., and Silvia Martinelli, PhD. as well as laboratory technicians Kevin Huynh and Akshara Vijay to the lab. Check out our People tab to learn more about their background and work. We are excited about all of our new members joining this summer!
New papers on bioRxiv! /
The lab has 3 new papers posted to bioRxiv, including our first foray into cryo-EM!
Congrats to all the authors!!!
https://www.biorxiv.org/content/10.1101/2023.08.16.553551v1
https://www.biorxiv.org/content/10.1101/2023.08.13.552748v1
https://www.biorxiv.org/content/10.1101/2023.08.28.555210v1
Welcome New Lab Members! /
The lab welcomes postdoctoral fellow Ipsit Srivastava, PhD., as well as laboratory technician Iram Arefin to the lab. Check out our People tab to learn more about their background and work. We are excited about all of our new members joining this fall!
Welcome New Lab Members! /
The lab welcomes graduate students Alexa Strauss, Matthew Bredder, and Giovanna Romano, as well as laboratory technician Mindy Kristt to the lab. Check out our People tab to learn more about their background and work. We are excited about all of our new members joining this summer!
New publication on developing cell-impermeable SNAP-tag substrates /
Congrats to lab members Vanessa Gutzeit and Joon Lee on the new publication in Chemical Science titled “Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates”. Great collaborative work that can be found here: https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc02794d#!divAbstract
Graduate student Vanessa Gutzeit awarded NIH NRSA F31 Fellowship /
Congrats to graduate student Vanessa Gutzeit on her awarded NRSA pre-doctoral fellowship!
Congrats to postdoc Joon Lee and others on new publication on mGluR dimerization in Cell Reports. /
The lab is happy to announce the publication of postdoc Joon Lee, with co-authors postdoc Hermany Munguba, graduate student Vanessa Gutzeit, and undergraduate student Mindy Kristt on the homo- and hetero-dimerization of mGluRs out in Cell Reports: https://www.cell.com/cell-reports/pdf/S2211-1247(20)30554-4.pdf
Lab publishes study on a new family of Branched Photoswitchable Ligands /
Congrats to graduate students and co-first authors Amanda Acosta-Ruiz and Vanessa Gutzeit, and the lab, on their new paper published in Neuron: Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo. DOI:https://doi.org/10.1016/j.neuron.2019.10.036
Welcome postdoc Hermany Munguba! /
The lab welcomes postdoctoral fellow Dr. Hermany Munguba, who will be working in both the Levitz and Dr. Conor Liston laboratories.
Welcome postdoc Guoqing Xiang! /
The lab welcomes postdoctoral fellow Dr. Guoqing Xiang, who will be working in both the Levitz and Dr. Francis Lee laboratories.
Congrats Georgia Krikorian for completing the Gateways Summer Undergraduate Program /
Thank you Georgia for a great summer in the lab!
Lab publishes new study in eLife on conformational dynamics of mGluR2. /
Congrats to the lab, especially graduate students Vanessa Gutzeit and Jordana Thibado, on a new publication in eLife: Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. DOI: 10.7554/eLife.45116
An inter-TMD FRET assay reveals LBD-independent reorientation in response to positive allosteric modulators.
Lab publishes book chapter protocol on using PORTLs /
Graduate student Amanda Acosta-Ruiz and Dr. Levitz, in collaboration with Dr. Broichhagen, published a chapter in G Protein-Coupled Receptor Signaling: Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands. https://link.springer.com/protocol/10.1007/978-1-4939-9121-1_6
Principle of PORTL-mediated Optical Control of Class C GPCRs.
Nohely Passes ACE Exam! /
Congrats to graduate student Nohely Abreu for passing her Admission to Candidacy (ACE) exam!
Lab publishes in ACS Chemical Biology /
Our paper on nanobody-mediated optical control of a GPCR is published in ACS Chemical Biology. Find it here: https://pubs.acs.org/doi/10.1021/acschembio.8b00628
Jordana attends The Protein Society Annual Symposium /
Jordana presented a poster titled "Optical Probing of Class C G Protein-Coupled Receptor Structure and Function" at the Protein Society Annual Symposium in Boston.
Dr. Levitz publishes review in Neuron /
A review by Dr. Levitz titled "Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert" was published this week in Neuron. Find it here: https://doi.org/10.1016/j.neuron.2018.05.018
Annual Lab Outing /
The lab enjoyed plenty of sunshine and great food at our lab outing!
The lab with our summer undergrads and baby Izzy.